9/18/2026
This is the third piece about David Phillips’s book High on Life: How to Naturally Harness the Power of Six Hormones and Revolutionize Yourself.
Today I'll talk about another chemical in Phillips’s framework: endorphins (内啡肽). One of the feelings he associates with endorphins is relief.
If dopamine functions like a gas pedal, helping motivate you to start running and reach your goal, endorphins can act more like a painkiller and a reward cushion, helping you cope with some of the discomfort that comes with exertion.
The two can work together. You may feel motivated when you think about going for a run. As you exercise, your body activates systems that help reduce the sensation of pain and discomfort.
Endorphins are natural chemicals produced by the brain and pituitary gland. They are part of the body's broader endogenous opioid system, which plays an important role in regulating pain, discomfort and other physiological processes.
You may have experienced something similar when you first start running or swimming. Your legs ache, you are out of breath, and your whole body seems to be telling you, You're tired. Stop.
When I was young, people sometimes called this 假疲劳—“false fatigue”—meaning that the initial discomfort might ease if you continued exercising for a while. There is some truth to the experience, although not every sensation of fatigue should simply be pushed through.
As exercise continues, especially when it becomes more intense, the body responds to the temporary physical stress in various ways. Among them is the activation of pain-relieving systems, including the endogenous opioid system, which can reduce the perception of discomfort.
This suggests an interesting way to regulate our emotions.
When we are in a bad mood or feeling uncomfortable, our first instinct may be to lie down, withdraw, or do nothing. But sometimes, instead of waiting for our mood to improve, we can give our bodies a small, manageable challenge: take a brisk walk, jog for a few minutes, swim, or do another form of exercise that raises our heart rate.
The goal is simply to get the body moving and give it something else to respond to.
Laughter is another interesting example. Research suggests that genuine laughter can activate the body's endogenous opioid system. In other words, laughter may be more than an outward expression of happiness; the act of laughing itself may contribute to how we feel.
Sometimes we don't laugh because we are happy. Sometimes we laugh first, and feeling better comes afterward.
Perhaps that is one of the simplest lessons from endorphins: we don't always have to wait for our feelings to change before we act. Sometimes, changing what we do can help change how we feel.
When your mind says, “I don't feel like doing anything,” maybe it's time to stand up and take a walk.
Finally, here's a progression across the first three hormones:
Dopamine: I want to do it.
Testosterone: I dare to do it.
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Endorphins: I can get through it.